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Phloridzin Mitigates Aging-Associated Periodontitis by Restraining Inflammatory Cell Death
Da Eun Lee1, Eun-Nam Kim1, Gil-Saeng Jeong1
1College of Pharmacy, Chungnam National University, Daejeon, Republic of Korea.
Journal of Periodontal Research
|July 31, 2026
Summary
Phloridzin protects against aging-related periodontitis by reducing inflammation and preserving bone. This natural compound may improve periodontal health in older adults.
Area of Science:
- Periodontology
- Gerontology
- Pharmacology
Background:
- Aging significantly impacts periodontitis progression, yet cellular mechanisms driving periodontal tissue damage remain unclear.
- Understanding aging's role is crucial for developing targeted therapies for age-associated periodontal diseases.
Purpose of the Study:
- To investigate phloridzin's protective effects against experimental periodontitis in aging.
- To determine phloridzin's role in mitigating aging-related alveolar bone loss.
Main Methods:
- Human periodontal ligament cells (HPDLCs) were induced into premature senescence using H2O2 to assess phloridzin's effects on senescence, inflammation, and osteogenesis.
- An aging-associated periodontitis rat model was created using D-galactose and ligature placement, with concurrent phloridzin administration.
- Alveolar bone loss, periodontal tissue morphology, and systemic aging/inflammation markers were analyzed in vivo.
Main Results:
- Phloridzin reduced oxidative stress-induced senescence and suppressed inflammation in HPDLCs, while preserving osteogenic capacity.
- In vivo, phloridzin significantly decreased alveolar bone loss and periodontal tissue damage in the aging periodontitis model.
- These findings highlight the importance of managing inflammation during aging for periodontal tissue health.
Conclusions:
- Phloridzin alleviates aging-associated alveolar bone loss by modulating inflammatory processes.
- Phloridzin shows potential for improving periodontal tissue function in aging individuals.
