The Serum Testosterone Level in Male Patients Is Inversely Associated With Hypertension Incidence

Area of Science:

• Endocrinology
• Cardiovascular Medicine
• Geriatrics

Background:

• Hypertension is a major risk factor for cardiovascular diseases and mortality.
• Testosterone, a key male androgen, influences metabolism and erythropoiesis.
• Aging is associated with increased hypertension incidence and declining testosterone levels.

Purpose of the Study:

• To investigate the association between serum testosterone levels and hypertension in men aged 40 and older.
• To evaluate the predictive role of serum testosterone for hypertension in different age groups.

Main Methods:

• Observational study of 3401 male patients aged ≥40 years admitted to a Cardiovascular Medicine Center.
• Analysis included linear relationships, generalized additive models, multivariate regression, and ROC curves.
• Data collected over a 4-year period.

Main Results:

• Hypertensive men (40-79 years) exhibited significantly lower serum testosterone than normotensive men.
• Multivariate regression revealed an inverse association between testosterone and hypertension.
• Serum testosterone showed modest predictive value for hypertension in men aged 40-60.
• Combining testosterone, age, smoking status, and BMI improved hypertension prediction in men aged 60-79.

Conclusions:

• Serum testosterone levels are inversely proportional to hypertension in older male patients.
• Testosterone serves as a modest predictor of hypertension in specific age groups.
• Clinical factors like age, BMI, and smoking status enhance testosterone's predictive value for hypertension in older men.