Related Experiment Video
Updated: Aug 5, 2026
10:07
Positron Emission Tomography Imaging of Cell Trafficking: A Method of Cell Radiolabeling
Published on: October 27, 2023
Radiolabeled exosomes for theranostics: Personalized tailored therapy through imaging
Soumya Deep Phadikar1, Aliza Hyder2, Ramya Lakshmi Rajendran3,4,5
1Department of Chemistry and Chemical Biology, Indian Institute of Technology (ISM), Dhanbad 826004, Jharkhand, India.
World Journal of Radiology
|July 31, 2026
Summary
Radiolabeled exosomes offer a powerful tool for nanomedicine and molecular imaging. This review covers their use in precision theranostics, imaging, and future clinical applications.
Area of Science:
- Nanomedicine
- Molecular Imaging
- Theranostics
Background:
- Exosomes are nanoscale extracellular vesicles with biocompatibility and targeting capabilities.
- Radiolabeling exosomes integrates radiochemistry with exosome biology for advanced imaging.
- This enables noninvasive tracking of biodistribution, pharmacokinetics, and target engagement.
Purpose of the Study:
- To summarize current radiolabeling strategies for exosomes.
- To discuss imaging platforms, biodistribution, and pharmacokinetic profiles.
- To address challenges and outline future perspectives for clinical translation.
Main Methods:
- Review of direct and indirect radiolabeling strategies.
- Analysis of imaging modalities like PET and SPECT.
- Discussion of in vivo biodistribution and pharmacokinetic data.
Main Results:
- Radiolabeling enhances exosome utility in diagnostics and therapeutics.
- Various labeling methods impact vesicle integrity and imaging accuracy.
- Challenges include mononuclear phagocyte system clearance and labeling instability.
Conclusions:
- Radiolabeled exosomes are a promising theranostic platform.
- They enable personalized, image-guided therapies in oncology and regenerative medicine.
- Future work focuses on bioengineering, multimodal imaging, and clinical frameworks.
