Related Experiment Videos
Association Between C-Reactive Protein-Triglyceride Glucose Index and All-Cause and Cardiovascular Mortality Across
Siqi Yi1, Weida Qiu1, Yanchen Zhu1
1Guangdong Provincial Key Laboratory of Coronary Heart Disease Prevention, Guangdong Cardiovascular Institute, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou 510080, China, fimmu.com.
Insights
The C-reactive protein-triglyceride glucose (CTI) index, reflecting insulin resistance and inflammation, is linked to higher mortality risks in advanced cardiovascular-kidney-metabolic (CKM) syndrome. Higher CTI levels correlate with increased all-cause and cardiovascular mortality across CKM stages.
Area of Science:
- Cardiology
- Nephrology
- Metabolic Syndrome Research
Background:
- Advanced cardiovascular-kidney-metabolic (CKM) syndrome significantly increases mortality risk.
- The C-reactive protein-triglyceride glucose (CTI) index measures insulin resistance and inflammation, key factors in CKM progression.
Purpose of the Study:
- To investigate the association between the CTI index and mortality risk in individuals with advanced CKM syndrome.
- To determine if this association varies across different stages of CKM progression.
Main Methods:
- Utilized data from 8314 American adults, categorized by advanced CKM stages.
- Calculated CTI using C-reactive protein, triglycerides, and fasting blood glucose levels.
- Employed logistic and Cox regression models to analyze associations with mortality.
Main Results:
- Higher CTI quartiles were significantly associated with a greater prevalence of advanced CKM stages (p < 0.001).
- Each standard deviation increase in CTI correlated with a 35% increase in all-cause mortality and a 40% increase in cardiovascular mortality.
- Participants in the highest CTI quartile (Q4) showed substantially higher risks for both all-cause (HR=1.82) and cardiovascular mortality (HR=2.29) compared to the lowest quartile (Q1).
Conclusions:
- Elevated CTI levels are linked to a higher prevalence of advanced CKM stages.
- CTI is independently associated with increased all-cause and cardiovascular mortality, irrespective of CKM stage.
- The CTI index may serve as a valuable tool for refining mortality risk assessment in CKM syndrome, warranting further validation.
Objective:
Advanced cardiovascular-kidney-metabolic (CKM) syndrome corresponds to an elevated risk of mortality. The C-reactive protein-triglyceride glucose index (CTI) reflects both insulin resistance and inflammation, processes that are crucial to CKM progression. However, it remains uncertain whether CTI is linked to mortality risk and how this relationship may vary across different CKM progression stages.
Methods:
A total of 8314 participants were drawn from American adults. Participants were then grouped by advanced CKM stages. CTI was calculated as 0.412 × Ln (CRP [mg/L]) + Ln (TG [mg/dl] × FBG [mg/dl])/2. The endpoints focused on all-cause and cardiovascular mortality. Associations of CTI with advanced CKM stages and mortality were examined using logistic and Cox regression models, respectively.
Results:
The highest CTI quartile (Q4) exhibited a markedly greater prevalence of advanced CKM stages relative to Q1 (p < 0.001). During a median follow-up of 152 months, 1606 participants died, including 475 cardiovascular deaths. Each SD increase in CTI was associated with a 35% higher risk of all-cause mortality (95% CI: 1.24-1.48) and a 40% higher risk of cardiovascular mortality (95% CI: 1.20-1.62). Similarly, compared with Q1, participants in Q4 of CTI had higher risks of all-cause mortality (HR = 1.82, 95% CI: 1.46-2.27) and cardiovascular mortality (HR = 2.29, 95% CI: 1.56-3.34), with homogeneous associations across different CKM stages (interaction p > 0.05).
Conclusion:
Higher CTI levels were accompanied by a greater prevalence of advanced CKM stages and were associated with increased risks of all-cause and cardiovascular mortality across CKM stages. CTI may provide complementary information for mortality-risk assessment although further validation is needed.
Related Concept Videos
01:19Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
01:30Coronary Artery Disease I: Introduction
01:25Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT
01:26Atherosclerosis III: Management