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Updated: Aug 5, 2026

Endoscopic Vacuum Therapy for the Treatment of Anastomotic Leakage after Total Gastrectomy with Esophagojejunostomy
Published on: August 22, 2025
Endoscopic Vacuum Therapy: When and How to Use It?
Nuno Gonçalves1, Inês Marques de Sá1
1Serviço de Gastrenterologia, Instituto Português de Oncologia do Porto, Porto, Portugal.
Endoscopic vacuum therapy (EVT) offers a minimally invasive treatment for gastrointestinal transmural defects, showing promising success rates. Further research is needed to standardize EVT techniques for complex cases and improve patient outcomes.
Area of Science:
- Gastroenterology
- Minimally Invasive Surgery
- Endoscopy
Background:
- Gastrointestinal (GI) transmural defects are serious conditions requiring prompt diagnosis and treatment.
- Minimally invasive therapeutic options are available, with endoscopic vacuum therapy (EVT) recently emerging as a new endoscopic treatment.
Purpose of the Study:
- To evaluate the role and effectiveness of EVT in managing GI transmural defects.
- To compare EVT with existing treatments like endoscopic stents.
- To identify optimal approaches for different defect types.
Main Methods:
- Review of clinical data and outcomes associated with EVT for GI transmural defects.
- Comparison of EVT's safety and efficacy profile against traditional endoscopic stents.
- Analysis of factors influencing treatment selection, including defect characteristics and patient status.
Main Results:
- EVT demonstrates promising clinical success rates and an acceptable safety profile.
- EVT is particularly effective for large, chronic, or complex defects with associated collections.
- Evidence regarding the optimal approach for specific defect types is still developing.
Conclusions:
- EVT represents a significant advancement in treating GI transmural defects, offering a less invasive alternative to surgery.
- Standardization of EVT techniques and development of new devices are necessary to overcome challenges and reduce complications.
- Personalized treatment selection based on defect specifics and clinical expertise is crucial for successful EVT implementation.
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