Prognostic Significance of SIRI and SII in Posttraumatic Hydrocephalus Following Traumatic Brain Injury

Area of Science:

• Neurosurgery
• Critical Care Medicine
• Inflammation Biology

Background:

• Traumatic brain injury (TBI) is a major cause of death and disability worldwide.
• Posttraumatic hydrocephalus (PTH) is a common complication following TBI surgery, posing diagnostic challenges.
• Limited clinical features and diagnostic scales hinder early detection of PTH.

Purpose of the Study:

• To identify risk factors for PTH following TBI surgery.
• To investigate the association of inflammatory markers, Systemic Inflammatory Response Index (SIRI) and Systemic Immune Inflammation Index (SII), with PTH.
• To explore the relationship between PTH, inflammatory markers, and patient outcomes.

Main Methods:

• Retrospective study of TBI surgery patients during intensive care unit (ICU) recovery.
• Data collection included demographics, blood, and biochemical parameters at admission.
• Analysis of risk factors and outcome associations using univariate and multivariable logistic regression models over a 2-year follow-up period.

Main Results:

• 12.42% of 443 TBI patients developed PTH.
• Univariate analysis identified decompressive craniectomy, meningitis, Glasgow Coma Scale (GCS), hospital stay, SIRI, and SII as associated with PTH.
• Multivariable analysis revealed preadmission GCS, ICU stay length, discharge GCS, and SII as significant predictors of PTH.
• Elevated SIRI and SII levels demonstrated a strong association with PTH occurrence.

Conclusions:

• SIRI and SII are significantly associated with the development of PTH after TBI.
• These inflammatory indices may serve as potential surrogate markers for early PTH risk detection.
• Further research in larger cohorts could validate SIRI and SII for improved PTH management and treatment strategies.