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Updated: Aug 5, 2026

In Vivo Inhibition of MicroRNA to Decrease Tumor Growth in Mice
07:02

In Vivo Inhibition of MicroRNA to Decrease Tumor Growth in Mice

Published on: August 23, 2019

[Retracted] MicroRNA‑365 inhibits proliferation, migration and invasion of glioma by targeting PIK3R3

Yonggang Zhu1, Hongguang Zhao2, Min Rao3

  • 1Department of Radiotherapy, China-Japan Union Hospital of Jilin University, Changchun, Jilin 130033, P.R. China.

Oncology Reports
|July 31, 2026
PubMed

Insights

This study was retracted due to concerns about duplicated and similar data in figures, including western blot and cell migration assays. The authors did not provide a satisfactory explanation, leading to the paper's retraction.

Area of Science:

  • Biomedical research integrity
  • Scientific publishing ethics

Background:

  • Concerns were raised regarding the duplication and similarity of western blot and cell migration/invasion assay data.
  • Data in Figs. 5, 6, 7, and 2C/D were found to be strikingly similar to those in other publications, including retracted ones.

Purpose of the Study:

  • To address allegations of data manipulation and duplication.
  • To maintain the integrity of published scientific literature.

Main Methods:

  • Editorial review of submitted data.
  • Comparison of figures with previously published research.

Main Results:

  • Identified apparent duplication of western blot data (Fig. 5D) with another publication.
  • Noted striking similarities between data in Figs. 5, 6, 7, and 2C/D and data from other sources, some retracted.
  • Authors failed to provide a sufficient explanation for the data discrepancies.

Conclusions:

  • The paper has been retracted due to significant concerns regarding data integrity.
  • The Editor apologizes for any inconvenience caused to the readership.
Keywords:
PIK3R3gliomainvasionmiR-365proliferation

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