Related Experiment Video
Updated: Aug 5, 2026

Establishment and Evaluation of a Sheep Model of Full-thickness Osteochondral Defect
Published on: April 14, 2026
Editorial Commentary: Cartilage Restoration Is Joint Preservation, and Joint Preservation Requires Treating the Whole
Jakob Ackermann1, Lee Friedman1, Alexis Sassower1
1Midwest Orthopaedics at Rush, Chicago, Illinois, U.S.A.
None:
Focal articular cartilage lesions of the knee rarely occur in isolation. Malalignment, meniscal deficiency, ligamentous instability, and patellofemoral maltracking frequently coexist, creating the mechanical environment in which cartilage restoration either succeeds or fails. In our view, the most important conceptual shift in cartilage surgery over the past decade has been the reframing of concomitant procedures (osteotomy, meniscal allograft transplantation, ligament reconstruction, and tibial tubercle osteotomy) from add-ons into graft-protecting interventions that address the drivers of the original lesion. Available evidence increasingly supports performing these procedures concomitantly at the index operation without compromising outcomes, and in the setting of malalignment or meniscal deficiency, it suggests improved survivorship. The literature remains heterogeneous and cannot yet define precise correction thresholds, ideal alignment targets, or a uniform definition of failure. Still, the governing principle is clear: cartilage restoration is joint preservation, and joint preservation requires treating the whole joint. Ultimately, progress in cartilage restoration will require more than better grafts, scaffolds, cells, or biologic augmentation. It will require a more precise understanding of the mechanical environment into which these restorative procedures are placed, supported by long-leg alignment imaging, meniscal and patellofemoral assessment, advanced imaging, gait analysis, and patient-specific risk modeling. Combined intervention strategies will optimize the knee organ environment and enhance the likelihood for disease modification over time with sustainable and meaningful outcomes.
More Related Videos
08:42Real-time Visualization and Analysis of Chondrocyte Injury Due to Mechanical Loading in Fully Intact Murine Cartilage Explants
Published on: January 7, 2019
11:22Treatment of Osteochondral Defects in the Rabbit's Knee Joint by Implantation of Allogeneic Mesenchymal Stem Cells in Fibrin Clots
Published on: May 21, 2013
Related Concept Videos
Growth of Cartilage and Bone Tissue
Bone Remodeling and Repair
Fractures: Bone Repair
Minor fractures with no bone displacement are treated by immobilizing the fractured bone using a cast or splint. However, in the case of fractures with displaced bones, the broken bones are repositioned before immobilization to ensure successful healing without deformation and loss of function. The realignment of fractured bone ends is performed through a process called reduction. If the procedure...
Degenerative Disc Disease I: Introduction
Bone Remodeling
Bone Formation by Endochondral Ossification