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Updated: Aug 5, 2026

Evidence-based Knowledge Synthesis and Hypothesis Validation: Navigating Biomedical Knowledge Bases via Explainable AI and Agentic Systems
Published on: June 13, 2025
From Static Outputs to Living Evidence: AI for Integrated Knowledge Translation in Canadian Health Research
Zack van Allen1,2, Jayne Beselt1, Jerry M Maniate1,3,4
1Bruyere Health Research Institute, 85 Primrose Ave, Ottawa, ON, K1R 6M1, Canada, 1 (613) 562-6262.
Unlabelled:
Integrated knowledge translation still relies on static reports, presentations, and manuscripts that cannot adapt to decision-makers' evolving questions. Retrieval-augmented large language models can add a secure, auditable conversational layer over curated program outputs and selected research materials, enabling rapid, traceable synthesis between meetings and across portfolios. Treating these tools as governed infrastructure, with mandatory provenance, privacy protections, transparent documentation, and equity by design, could help reduce friction in evidence exchange and shorten the lag between knowledge creation and use. This viewpoint paper advances a conceptual design vision and the governance it requires, rather than reporting an evaluation of a deployed system.
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