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Published on: January 22, 2013
Papillary renal neoplasm with reverse polarity: A case report
Taoze Ji1, Boshi Wang2, Xin Guan1
1Department of Urology, Northern Jiangsu People's Hospital, China.
The Journal of International Medical Research
|July 31, 2026
Summary
This study details a rare papillary renal neoplasm with reverse polarity, a kidney cancer subtype. It highlights an atypical imaging finding and confirms pathological diagnosis for this favorable prognosis tumor.
Area of Science:
- Nephrology
- Oncology
- Pathology
Background:
- Papillary renal neoplasm with reverse polarity is a rare subtype of papillary renal cell carcinoma originating from distal renal tubules.
- It presents unique histomorphological and immunophenotypic features.
- Typically, it shows a slow enhancement pattern on contrast-enhanced scans and has a favorable prognosis.
Purpose of the Study:
- To report a case of papillary renal neoplasm with reverse polarity exhibiting atypical imaging enhancement.
- To enrich the understanding of the clinical and imaging spectrum of this rare kidney tumor.
- To emphasize the diagnostic role of pathological examination and immunohistochemistry.
Main Methods:
- Case report of a male patient in his 50s with left lumbar pain.
- Computed tomography (CT) and contrast-enhanced CT for imaging.
- Laparoscopic partial nephrectomy followed by histopathological examination (hematoxylin and eosin staining).
Main Results:
- CT revealed a quasi-circular, isodense lesion (1.3 × 0.8 cm) in the left kidney.
- Atypical finding: contrast-enhanced scan showed a rapid wash-in and wash-out pattern.
- Pathology confirmed papillary structures, eosinophilic cytoplasm, basally displaced nuclei, and specific stromal features consistent with the diagnosis.
Conclusions:
- Papillary renal neoplasm with reverse polarity can present with atypical rapid enhancement on contrast-enhanced scans.
- Pathological examination remains the gold standard for diagnosis.
- This case provides a valuable reference for the identification and differential diagnosis of this rare renal neoplasm.
