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Stiff matrix impairs cytotoxic T lymphocyte function at multiple levels

Mir Hadi Seyedzadeh1, M A Tolentino2, Newton Gil Peres1

  • 1Department of Molecular Medicine, School of Biomedical Sciences, Faculty of Medicine and Health, University of New South Wales Sydney, Sydney, Australia.

Science Advances
|July 31, 2026
PubMed
Summary

Tumor stiffness impairs cytotoxic T lymphocyte (CTL) function. Stiffer tumor microenvironments reduce CTL migration, cytotoxicity, and immune synapse formation, hindering antitumor immunity.

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