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Radiographic Progression With and Without Prostate-Specific Antigen Rise in Patients With Advanced Prostate Cancer

Ahmet Oruç1, Mustafa Erol1

  • 1Ahmet Oruç, MD, Department of Medical Oncology, Necmettin Erbakan University, Konya, Turkey; and Mustafa Erol, MD, Department of Nuclear Medicine, Necmettin Erbakan University, Konya, Turkey.

Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
|July 31, 2026
PubMed
Abstract

No abstract available in PubMed .

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Tumor Progression

Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...