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Updated: Aug 5, 2026
09:02
A Large Animal Model for Acute Kidney Injury by Temporary Bilateral Renal Artery Occlusion
Published on: February 2, 2021
Accelerating Evidence-Based Practices in Acute Kidney Injury: A Consensus Statement from the XXXV ADQI Conference
Jeremiah R Brown1, Oleksa G Rewa2, Borsika A Rabin3
1Dartmouth Center for Implementation Science, Departments of Epidemiology, Medicine, Health Policy, Geisel School of Medicine at Dartmouth, Hanover, NH, USA.
Summary
Implementation science (IS) bridges the gap between evidence-based practices (EBPs) and clinical care for acute kidney injury (AKI). This consensus defines IS
Area of Science:
- Implementation science in nephrology
- Translational research in kidney care
- Evidence-based practice adoption
Background:
- Significant advancements in scientific evidence for acute kidney injury (AKI) and acute kidney care exist.
- A gap persists in translating this evidence into effective clinical practices.
- Implementation science (IS) aims to bridge this gap for efficient and sustainable healthcare.
Purpose of the Study:
- To define the current state of IS in AKI and acute kidney care.
- To outline a roadmap for accelerating IS, emphasizing patient advocacy, digital tools, social determinants of health, and resource-limited settings.
- To develop a research agenda integrating IS methodologies into AKI programs.
Main Methods:
- A modified Delphi process with virtual and in-person meetings.
- Five a priori workgroups focused on IS definitions, literature, innovations, resource-limited settings, and EBP evaluation.
- Consensus was achieved through iterative discussions and voting (≥80% agreement).
Main Results:
- A structured, multidisciplinary consensus on the role of IS in AKI and acute kidney care was established.
- Key areas for IS focus include patient advocacy, digital tools, social determinants, and resource-limited settings.
- A research agenda was developed to guide future IS efforts in AKI.
Conclusions:
- The consensus provides a framework for applying IS methodology to AKI care.
- Future programs should address consensus questions to improve the translation of science into practice.
- This work facilitates the implementation and de-implementation of evidence-based practices in AKI.
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