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Published on: November 23, 2016
Anti-Inflammatory Potentials of Anacardium Occidentale L. Nut Methanol Extract in Wistar Rats
Gbenga Olayinka1, Oyetola Oyebanjo2, Mujeedat Olubori3
1Neurosciences and Oral Physiology Unit, Department of Physiology, Faculty of Basic Medical Sciences, College of Medicine, University of Ibadan, Ibadan, Nigeria.
Abstract:
The Anacardium occidentale nut is increasingly gaining attention due to its economic, nutritional value and biological properties. This study is aimed at evaluating the anti-inflammatory potential of Anacardium occidentale nut Methanol extract (AOME) in carrageenan-induced paw oedema and the carrageenan-induced air pouch models of inflammation. AOME (200 mg/kg) significantly (p<0.05) inhibited carrageenan-induced increase in paw volume and increase in paw size, respectively, at 5 hours post-carrageenan injection. In the carrageenan induced air pouch inflammation model, 200 mg/kg AOME significantly (P<0.05) reduced exudate volume, Total leucocyte count, Neutrophil cell count, Monocyte count and Lymphocyte count. 200 mg/kg AOME also reduced significantly MDA, Nitrite, TNF-α, IL-6, and significantly increased GSH and catalase levels. Anacardium occidentale nuts showed anti-inflammatory effects through reduction in lipid peroxidation and TNF-α and IL-6 activity, alongside amelioration of oxidative stress.
