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Comparative Effects of Fucoidan and Papain on Biliary Flow Rate and Electrolytes in Wistar Rats
Irene Atim1, Polycarp Adie2, Minafuro Okwejie Chijindu3
1University of Calabar.
Summary
This study found that papain and fucoidan enzymes modulate biliary electrolyte levels and bile flow rate. Both compounds demonstrate regulatory effects on biliary secretion, suggesting potential hepatoprotective benefits.
Area of Science:
- Biochemistry
- Pharmacology
- Gastroenterology
Background:
- Papain and fucoidan are enzymes with recognized applications in food, pharmaceuticals, and digestion.
- Their specific impact on bile flow rate and electrolyte composition remains largely uncharacterized.
Purpose of the Study:
- To comparatively evaluate the effects of papain and fucoidan on bile flow rate and biliary electrolytes.
- To investigate the potential hepatoprotective and stabilizing properties of these enzymes.
Main Methods:
- Twenty male Wistar rats were divided into four groups: control, papain (800mg/kg), fucoidan (800mg/kg), and metoclopramide (30mg/kg).
- Administration occurred over 28 days, with subsequent collection and analysis of bile for flow rate and electrolyte composition (sodium, chloride, bicarbonate).
Main Results:
- Papain significantly altered biliary sodium and chloride levels, decreasing bicarbonate, but did not affect bile flow rate compared to controls.
- Fucoidan demonstrated significant effects on biliary sodium and chloride, as well as bile flow rate, relative to the control group.
- Metoclopramide served as a positive control, showing expected effects on biliary parameters.
Conclusions:
- Both papain and fucoidan exhibit regulatory, rather than stimulatory, effects on biliary secretion.
- These findings support the potential hepatoprotective and stabilizing roles of papain and fucoidan in liver function.