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Correlation analysis of metabolically healthy obesity and erectile dysfunction: a cross-sectional study based on the
Yuchao Hou1, Guangcai Yu1, Chengyu Zhang1
1Department of Urology, Xiangyang No.1 People's Hospital, Hubei University of Medicine, Xiangyang, China.
Objective:
To explore the relationship between metabolically healthy obesity (MHO) and erectile dysfunction (ED).
Methods:
Using National Health and Nutrition Examination Survey (NHANES) data from 2001 to 2004, 974 participants were classified into ED and non-ED groups. MHO diagnosis combined BMI-based obesity assessment with metabolic status evaluation per National Cholesterol Education Program-Adult Treatment Panel III (ATP III) criteria. Weighted univariate and multivariate logistic regression models assessed the association between obesity subtypes and ED. Subgroup analyzes examined association stability across populations. Two-sample Mendelian randomization (MR) evaluated causal relationships between individual metabolic syndrome criteria and ED occurrence.
Results:
In the optimized model, MHO was not associated with significantly increased ED risk compared to non-obese individuals. Metabolically abnormal obesity was associated with a 13% higher ED risk versus non-obese individuals (OR = 1.13, 95% CI: 1.02-1.25, p = 0.019). Subgroup analyzes showed no significant effect modification across subgroups (p > 0.05). Combined BMI and metabolic indicators demonstrated stronger predictive ability for ED than BMI alone, with waist circumference showing the strongest individual correlation (p = 0.001).
Conclusion:
MHO does not confer elevated ED risk. Metabolically abnormal obesity is associated with a 14% increased ED risk compared to non-obese individuals.
