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Physicochemical developability insights into human Fab fragments with extended hypervariable loops

Marcel Passon1, Gianluca Bandera2, Leonard Mayerhöfer2

  • 1Faculty of Pharmaceutical Sciences, Ghent University, Ottergemsesteenweg 460, 9000, Ghent, Belgium; Biopharmaceutical Technology, TUM School of Life Sciences, Technical University of Munich, Emil-Erlenmeyer-Forum 5, 85354, Freising, Germany.

Journal of Pharmaceutical Sciences
|July 31, 2026
PubMed

Keywords:
Antibody(s)DevelopabilityLong CDRsMolecular dynamicsNon-specific bindingPhysical stabilityProtein aggregation

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