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Periprosthetic joint infection : lessons from the INFORM research programme
Andrew J Moore1, Andrew D Beswick1,2, Michael R Whitehouse1,2
1Musculoskeletal Research Unit, Translational Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.
The Bone & Joint Journal
|July 31, 2026
Summary
Surgical site infections after arthroplasty are a major concern. The INFection ORthopaedic Management (INFORM) program developed evidence-based guidelines for preventing and managing these infections, focusing on hip and knee replacements.
Area of Science:
- Orthopaedic Surgery
- Infectious Diseases
- Public Health
Background:
- Arthroplasty infections pose significant challenges in patient outcomes and healthcare costs.
- The National Institute for Health and Care Research (NIHR) initiated the INFection ORthopaedic Management (INFORM) research programme to address this critical issue.
Purpose of the Study:
- To comprehensively study arthroplasty infections.
- To translate research findings into practical clinical guidelines (INFORM guidelines).
Main Methods:
- Multinational research programme (INFORM) encompassing various studies.
- Evidence synthesis and guideline development (INFORM: Evidence into Practice).
Main Results:
- Identification of key risk factors, impact, diagnosis, and treatment strategies for arthroplasty infections.
- Development of evidence-based guidelines for hip and knee arthroplasty.
Conclusions:
- High-quality evidence from the INFORM programme underpins the developed guidelines.
- Future research directions are proposed to further combat arthroplasty infections.
