Related Experiment Video
Updated: Aug 5, 2026
08:35
Improved Renal Denervation Mitigated Hypertension Induced by Angiotensin II Infusion
Published on: May 26, 2022
Recent updates and perspectives in "Onco-hypertension"
Satoshi Kidoguchi1, Takashi Yokoo2
1Division of Nephrology and Hypertension, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, Japan. s.kidoguchi@jikei.ac.jp.
Summary
Cancer survivors face increased risks of hypertension and cardiovascular disease. This review explores the link between hypertension and cancer, focusing on survivors and treatment impacts.
Area of Science:
- Cardiovascular Medicine
- Oncology
- Hypertension Research
Background:
- Improved cancer treatments increase long-term survival, creating a growing population of cancer survivors.
- Hypertension and cardiovascular disease are significant concerns in cancer survivors.
- The field of Onco-Hypertension investigates the complex relationship between cancer and hypertension.
Purpose of the Study:
- To review the association between hypertension and cancer incidence/recurrence.
- To examine hypertension development in childhood cancer survivors and screening implications.
- To explore hypertension, blood pressure variability, and cardiovascular complications in patients undergoing anticancer therapies.
- To assess antihypertensive agents for managing treatment-induced hypertension and cardiotoxicity.
- To evaluate treatment-induced hypertension as a prognostic marker in cancer patients.
Main Methods:
- Comprehensive literature review focusing on articles published in Hypertension Research in 2025.
- Analysis of the relationship between hypertension and cancer incidence, recurrence, and survivorship.
- Examination of cardiovascular complications in patients receiving anticancer therapies.
- Discussion of current research and future directions in Onco-Hypertension.
Main Results:
- Hypertension is linked to cancer incidence and recurrence.
- Childhood cancer survivors are at risk for developing hypertension.
- Anticancer therapies can induce hypertension and cardiotoxicity.
- Blood pressure variability is associated with cardiovascular complications.
- Treatment-induced hypertension may serve as a prognostic marker.
Conclusions:
- Onco-Hypertension is a critical emerging field for managing cancer patient and survivor health.
- Further research is needed to understand hypertension's role in cancer and optimize management strategies.
- Clinical guidelines for screening and managing hypertension in cancer patients and survivors require development.
Related Concept Videos
01:29Hypertension II: Pathophysiology
Hypertension is a chronic condition in which the blood's force against artery walls is excessively high, posing risks such as heart disease. The condition's underlying mechanisms involve complex interactions among the cardiovascular, kidney, and autonomic nervous systems.Renin-Angiotensin-Aldosterone System (RAAS): This system significantly influences blood pressure regulation. When blood pressure decreases, the kidneys secrete renin. This enzyme transforms angiotensinogen, a plasma protein,...
01:23Hypertension V: Nursing Management
The nursing management of hypertension involves accurately assessing symptoms, making a comprehensive nursing diagnosis, collaborating with patients to set goals, and implementing targeted interventions to mitigate the condition's impact and improve patient well-being.Comprehensive AssessmentThe initial step in nursing care for hypertension involves a thorough patient assessment. It includes evaluating symptoms such as headaches, dizziness, blurred vision, and previous hypertension episodes.
01:30Hypertension III: Clinical Manifestations and Diagnostic Studies
Hypertension is asymptomatic and also referred to as the "silent killer" until it progresses to a severe stage or causes target organ disease. Patients may experience symptoms stemming from the strain on blood vessels and tissues in various organs or the heart's increased workload.Physical exams might show no abnormalities other than high blood pressure. Signs of vascular damage, when present, correspond to the organs supplied by the affected vessels, leading to target organ damage. For...
01:28Hypertension I: Introduction
Hypertension is a widespread, long-term medical condition where blood pressure in the arteries remains elevated. It is characterized by systolic blood pressure readings of 130 mm Hg or above or diastolic blood pressure (DBP) readings of 80 mm Hg or higher. Unmanaged hypertension poses significant health risks, making the distinction between primary (or essential) hypertension and secondary hypertension crucial, as their management and implications vary.Primary HypertensionPrimary hypertension,...
01:18Hypertension and Regulation of Blood Pressure
Hypertension, the most common cardiovascular disease, is diagnosed through repeated measurements of elevated blood pressure. Its risks, including damage to the kidney, heart, and brain, are directly proportional to blood pressure levels. Starting from 115/75 mm Hg, the risk of cardiovascular disease doubles with each increment of 20/10 mm Hg. The diagnosis relies on blood pressure measurements, not on patient symptoms, as hypertension is often asymptomatic until end-organ damage is imminent or...
01:28Hypertension IV: Drug Therapy and Lifestyle Modifications
Multiple classes of antihypertensive medications are employed in treating hypertension. The most commonly recommended first-line treatments include:Thiazide Diuretics, such as chlorthalidone, increase sodium and water excretion from the body, reducing blood volume and blood pressure.Angiotensin-converting enzyme inhibitors, like lisinopril, block the conversion of angiotensin I to II, a potent vasoconstrictor lowering blood pressure.Angiotensin II Receptor Blockers (ARBs) prevent angiotensin II...