Related Experiment Video
Updated: Aug 5, 2026
07:58
Orthotopic Kidney Auto-Transplantation in a Porcine Model Using 24 Hours Organ Preservation And Continuous Telemetry
Published on: August 21, 2020
ABO-Incompatible Kidney Transplantation as a Strategic Expansion Tool in Low- and Middle-Income Countries
Mohamed Mongi Bacha1, Aziz El Matri, Ezzedine Abderrahim
1From the Department of Nephrology, Charles Nicolle Hospital,University Tunis El Mana,Research Laboratory in Immunology of Renal Transplantation and Immunopathology (LR03SP01), Charles Nicolle Hospital-Ministry of Higher Education and Scientific Research, University Tunis El Manar, Tunisia.
Summary
ABO-incompatible kidney transplants expand living donor availability, offering survival rates comparable to compatible transplants. This mature strategy is feasible in low- and middle-income countries with cost adaptations.
Area of Science:
- Nephrology
- Transplant Surgery
- Immunology
Background:
- Global organ shortages severely limit kidney transplantation.
- ABO-incompatible kidney transplantation has evolved into a viable strategy to increase donor availability.
- This review assesses its suitability for low- and middle-income countries.
Purpose of the Study:
- To critically evaluate ABO-incompatible kidney transplant as a justified, effective, and feasible solution in low- and middle-income countries.
- To review epidemiological data, clinical outcomes, and economic implications.
Main Methods:
- Structured review of international registry data, meta-analyses, and major cohort studies.
- Assessment of historical evolution, immunologic principles, desensitization protocols, and complication profiles.
Main Results:
- ABO-incompatible kidney transplants increase living donor availability by 25-33%.
- Graft and patient survival rates approach those of compatible transplants, despite higher early risks.
- Advances in therapies improve outcomes, with cost being the main barrier in LMICs, though cost-reduction strategies exist.
Conclusions:
- ABO-incompatible kidney transplantation is a mature, evidence-supported strategy, not experimental.
- It offers a reasonable and potentially transformative approach to mitigate organ shortages in LMICs.
- Implementation requires experienced centers, appropriate protocols, and cost-adaptation measures.
Related Concept Videos
01:28Kidney Transplant I: Introduction
A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
01:26Kidney Transplant II: Surgical Procedure
Preoperative ManagementThe primary goals of preoperative management in kidney transplantation are to optimize the patient’s metabolic state and prepare them for surgery through diet adjustments, necessary dialysis, and tailored medical treatment. This phase also involves comprehensive infection screening and patient education about the surgical procedure and postoperative care to improve outcomes and adherence.Medical ManagementA comprehensive evaluation is required for both the living donor...
01:16Kidney Transplant III: Nursing Management
Postoperative Nursing Management for Kidney Transplant PatientsPostoperative nursing management care includes monitoring the surgical site, encouraging early movement, and promoting lung health through breathing exercises. Nurses also administer prescribed medications like H2-blockers, such as famotidine, or proton pump inhibitors, like omeprazole, to help prevent gastrointestinal ulcers and bleeding. Fungal infections in the mouth and bladder can result from immunosuppressive and antibiotic...
01:22Bone Marrow Sampling and Transplants
Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy the...
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy the...
01:24Tissue Transplantation
Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...