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Updated: Aug 5, 2026

Measuring G-protein-coupled Receptor Signaling via Radio-labeled GTP Binding
10:13

Measuring G-protein-coupled Receptor Signaling via Radio-labeled GTP Binding

Published on: June 9, 2017

Ligand-Specified Signaling Efficacy Defined by Unique Transitions in G Protein Conformations

Xudong Wang, Wenkai Sun, Nathaniel Hays

    Biorxiv : the Preprint Server for Biology
    |August 1, 2026
    PubMed
    Summary

    Understanding G protein-coupled receptor (GPCR) activation requires dynamic insights. This study uses 19F-quantitative NMR to reveal how Gαs protein conformational dynamics dictate GPCR signaling specificity.

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