Implementing the National Alzheimer's Coordinating Center Uniform Data Set (v3) within the Diabetes Prevention...

Area of Science:

• Gerontology
• Neuroscience
• Epidemiology

Background:

• The Diabetes Prevention Program Outcomes Study (DPPOS) is a 30-year follow-up of a trial preventing type 2 diabetes (T2D) in prediabetes adults.
• Cognitive assessments were expanded in 2022 to include Alzheimer's disease (AD) and AD-related dementias (ADRD) in the DPPOS cohort.
• The National Alzheimer's Coordinating Center Uniform Data Set version 3 (NACC-UDSv3) was implemented to standardize data for AD/ADRD research and enable data sharing.

Purpose of the Study:

• To integrate the NACC-UDSv3 into the longitudinal DPPOS framework for cognitive impairment research.
• To maintain the fidelity of the existing DPPOS structure during integration.
• To develop automated reports for streamlining cognitive outcomes adjudication.

Main Methods:

• Harmonized DPPOS and NACC-UDSv3 data by comparing, integrating, and adding items.
• Adapted NACC-UDSv3 forms for electronic data capture (EDC) using the Multimodal Integrated Data Acquisition System (MIDAS).
• Utilized automated reports integrating current and prior neuropsychological scores for adjudications.

Main Results:

• Successfully integrated NACC-UDSv3 into the DPPOS framework.
• Completed 1561 cognitive adjudications using harmonized data and EDC in the first wave of the DPPOS-AD/ADRD study.
• Demonstrated successful data harmonization and electronic capture.

Conclusions:

• NACC-UDSv3 can be successfully integrated into long-standing longitudinal cohorts for AD/ADRD research.
• The harmonization, EDC, and automated adjudication processes offer a practical framework for other cohorts.
• This approach aligns research with national AD/ADRD research standards.