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Updated: Aug 5, 2026
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Fabrication and Characterization of a Conformal Skin-like Electronic System for Quantitative, Cutaneous Wound Management
Published on: September 2, 2015
Self-powered electronics-free Wearable Disposable Electrotherapy (WDE) platform for accelerated wound healing
Mojtaba Belali Koochesfahani1, Kyle Donnery1, Abhiramalakshmi Senthil Kumar1
1The City College of New York, Dept of Biomedical Engineering.
Biorxiv : the Preprint Server for Biology
|August 1, 2026
Summary
A new wearable disposable electrotherapy (WDE) patch accelerates wound healing by delivering electrical stimulation like a bandage. This innovative device speeds up wound closure and enhances tissue repair, offering a practical solution for wound care.
Area of Science:
- Biomedical Engineering
- Regenerative Medicine
- Wound Healing Research
Background:
- Electrical stimulation accelerates wound repair by modulating bioelectric signals.
- Clinical translation is limited by cumbersome devices and workflow disruption.
- Wearable Disposable Electrotherapy (WDE) offers a novel, bandage-like approach.
Purpose of the Study:
- Evaluate the efficacy of WDE in a rat wound model.
- Compare WDE performance to sham treatment and conventional electrotherapy.
- Establish a biophysical framework for electrical stimulation in wound healing.
Main Methods:
- A full-thickness excisional wound model in rats was used.
- WDE, sham, and Constant Current (CC) stimulators were applied daily for 13 days.
- Histological and immunofluorescence analyses assessed tissue remodeling markers.
Main Results:
- WDE reduced time to 50% wound closure by ~29% compared to sham.
- Enhanced collagen deposition (~25%) and cellularity (~73%) were observed.
- Increased expression of myofibroblast (αSMA), angiogenesis (CD31), and immune markers (M1/M2) were noted.
Conclusions:
- WDE is a practical bioelectric wound dressing that accelerates healing and tissue remodeling.
- The device offers simplicity and scalability comparable to disposable bandages.
- A novel dosimetry model links electrical stimulation to wound repair mechanisms.
