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Dynamic Digital Biomarkers of Motor and Cognitive Function in Parkinson's Disease
Published on: July 24, 2019
An efficient multiplier-based FPGA CNN accelerator for Parkinson's disease detection using hand-drawn circle images
VedanthSrivatson A1, Sivanantham Sathasivam1, Prakash Ramachandran1
1School of Electronics Engineering, Vellore Institute of Technology, Vellore, Tamil Nadu, India.
Frontiers in Artificial Intelligence
|August 1, 2026
Summary
This study developed a Field-Programmable Gate Array (FPGA)-based convolutional neural network (CNN) for Parkinson's disease handwriting classification. Optimized multipliers on FPGA hardware show potential for efficient edge healthcare applications.
Area of Science:
- Artificial Intelligence
- Biomedical Engineering
- Computer Engineering
Background:
- Parkinson's disease (PD) diagnosis can be aided by analyzing handwriting patterns.
- Field-Programmable Gate Arrays (FPGAs) offer efficient hardware acceleration for machine learning models.
- Optimized multiplier architectures are crucial for enhancing the performance of neural network accelerators.
Purpose of the Study:
- To develop and evaluate an FPGA-based convolutional neural network (CNN) accelerator for Parkinson's disease (PD) handwriting classification.
- To investigate the impact of different multiplier architectures (standard, approximate logarithmic, Karatsuba) on the accuracy and hardware efficiency of the CNN.
- To assess the feasibility of deploying lightweight CNNs with optimized multipliers for resource-constrained edge healthcare applications.
Main Methods:
- A lightweight binary CNN classifier was trained and deployed on FPGA hardware.
- Three multiplier architectures were evaluated: standard, approximate logarithmic, and Karatsuba.
- The model was quantized to Q4.12 fixed-point precision, and hardware inference was validated on the NewHandPD dataset, comparing FPGA outputs with software results using Mean Absolute Deviation (MAD).
Main Results:
- FPGA implementation achieved classification behavior closely aligned with software inference, demonstrating improved hardware efficiency.
- Under non-augmentation validation, FPGA accuracy was 89.73% (vs. 92.86% software); with standard augmentation, FPGA accuracy was 95.40% (vs. 97.83% software) using the Approximate Logarithmic Multiplier.
- The Approximate Logarithmic Multiplier showed promising results in balancing accuracy and efficiency for FPGA deployment.
Conclusions:
- Lightweight CNNs with optimized multipliers are feasible for resource-efficient edge healthcare applications, particularly for preliminary PD handwriting classification.
- The study serves as a proof-of-concept, highlighting the potential of hardware acceleration for medical diagnostics.
- Further validation with larger datasets is recommended for definitive clinical application.