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Imaging strategies for delineating glioma margins: Aiming at precise therapy
Jun Tang1, Liangpeng Chen1, Ziyang Li1
1Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, China.
Abstract:
Surgical resection aiming at maximal safe resection is the primary treatment for gliomas. However, the infiltrative growth characteristics of gliomas make it challenging to determine tumor margins, and traditional structural imaging provides assistance to neurosurgeons but not enough. In recent years, with a deepening understanding of gliomas, various features of tumor cells, tumor metabolism, and the tumor microenvironment have been discovered, some of which can serve as targets for glioma visualization. Based on these new findings, a range of visualization techniques have been developed, offering powerful tools for the precise identification of glioma margins. This review aims to describe the current state of research on glioma identification, summarizing the characteristics and implications of various glioma imaging technologies and discussing their advantages and limitations in tumor margin delineation. Importantly, novel imaging techniques that will potentially push forward the development in this challenging field are foreseen as well.
Insights
Accurate glioma margin identification is crucial for maximal safe resection. New imaging techniques offer improved visualization beyond traditional methods, aiding neurosurgeons in precise tumor delineation.
Area of Science:
- Neuro-oncology
- Medical Imaging
- Surgical Oncology
Background:
- Gliomas are challenging to resect completely due to their infiltrative nature.
- Traditional structural imaging offers limited precision for defining glioma margins.
- Advances in understanding glioma biology reveal new targets for visualization.
Purpose of the Study:
- To review current glioma identification research.
- To summarize various imaging technologies for glioma margin delineation.
- To discuss the advantages and limitations of existing and novel techniques.
Main Methods:
- Literature review of glioma imaging technologies.
- Analysis of current research on tumor cell, metabolism, and microenvironment visualization.
- Discussion of novel imaging techniques for precise margin identification.
Main Results:
- Various imaging techniques have been developed based on new biological insights.
- These techniques provide powerful tools for precise glioma margin identification.
- Each technique has distinct advantages and limitations in tumor delineation.
Conclusions:
- Novel imaging technologies are essential for advancing glioma surgery.
- Improved visualization techniques enhance the ability to achieve maximal safe resection.
- Future research should focus on developing and validating new imaging modalities.
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