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Bone Fractures in People with Hemophilia
1Department of Orthopedic Surgery, La Paz University, Madrid, Spain.
The Archives of Bone and Joint Surgery
|August 1, 2026
Summary
Bone fractures in people with hemophilia (PWH) require factor replacement therapy for hemostasis. While healing times are similar to the general population, PWH experience more frequent fractures, often linked to osteoporosis or pathological causes.
Area of Science:
- Orthopedics
- Hematology
Background:
- People with hemophilia (PWH) face unique challenges with bone fractures.
- Fractures in PWH are more common, potentially due to osteoporosis.
- Pathological fractures can occur from hemophilic pseudotumors eroding bone.
Purpose of the Study:
- To review current literature on managing bone fractures in PWH.
- To highlight specific considerations for fracture treatment in this population.
Main Methods:
- Literature review of existing studies on hemophilia and bone fractures.
- Analysis of treatment protocols and outcomes.
Main Results:
- Fracture treatment in PWH mirrors that in healthy individuals, with added perioperative hemostasis control.
- Healing duration for fractures in PWH is comparable to the general population.
- Increased fracture incidence in PWH is likely associated with osteoporosis.
Conclusions:
- Fractures in PWH necessitate factor replacement therapy for adequate hemostasis.
- Pathological fractures due to pseudotumors require management similar to other etiologies.
- Vigilance for acute compartment syndrome in PWH with fractures is crucial.
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