Molybdenum Nanoparticles Alleviate Psoriasis-Related Cardiovascular Oxidative Stress and Inflammation

Area of Science:

• Immunodermatology
• Cardiovascular Medicine
• Nanomedicine

Background:

• Psoriasis is a chronic inflammatory disease with multisystem comorbidities, including cardiovascular diseases.
• Cardiovascular complications in psoriasis patients can be fatal, necessitating research into underlying mechanisms and treatments.
• Oxidative stress and inflammation are implicated in psoriasis-related cardiovascular issues.

Purpose of the Study:

• To investigate the therapeutic effect of molybdenum nanoparticle suspension (MNS) on cardiovascular inflammation in a mouse model of psoriasis.
• To explore the role of the reactive oxygen species (ROS)/nuclear factor-kappa B (NF-κB) axis in psoriasis-related cardiovascular oxidative stress and inflammation.

Main Methods:

• Psoriasis model mice were treated with MNS.
• Cardiovascular tissues were analyzed for reactive oxygen species (ROS) content, inflammatory cell infiltration, and expression of inflammatory mediators (TNF-α, IFN-γ, IL-1β, IL-6, IL-17).
• Cardiomyocyte hypertrophy was assessed in MNS-treated and untreated psoriasis model mice.

Main Results:

• MNS treatment significantly decreased ROS levels, inflammatory cell infiltration, and expression of key inflammatory mediators in the cardiovascular tissues of psoriasis model mice.
• MNS intervention alleviated cardiomyocyte hypertrophy observed in the psoriasis model group.
• The study suggests a link between the ROS/NF-κB axis and psoriasis-related cardiovascular oxidative stress and inflammation.

Conclusions:

• Molybdenum nanoparticle suspension demonstrates a protective effect against cardiovascular inflammation and oxidative stress in a psoriasis mouse model.
• MNS may represent a potential therapeutic agent for managing cardiovascular comorbidities associated with psoriasis.
• Targeting the ROS/NF-κB pathway could be a viable strategy for treating psoriasis-related cardiovascular complications.