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Capecitabine-Induced Hand-Foot Syndrome With Genital Involvement
Yue Feng1, Christina Baroody1, Salwan Al Mutar1
1From Harold C. Simmons Comprehensive Cancer Center, UT Southwestern Medical Center, Dallas, Texas.
Journal of the Advanced Practitioner in Oncology
|August 1, 2026
Summary
Capecitabine can cause hand-foot syndrome (HFS), a skin reaction. This case highlights rare genital HFS, emphasizing the need for early recognition and management of this side effect.
Area of Science:
- Oncology
- Dermatology
- Pharmacology
Background:
- Palmar-plantar erythrodysesthesia, or hand-foot syndrome (HFS), is a frequent adverse effect of capecitabine chemotherapy.
- HFS typically manifests as redness, swelling, and pain on the palms and soles.
Purpose of the Study:
- To report a rare case of grade 2 HFS with atypical genital involvement in a patient receiving capecitabine.
- To emphasize the importance of identifying and managing unusual presentations of capecitabine-induced HFS.
Main Methods:
- Case report of a 59-year-old male patient with metastatic pancreatic ductal adenocarcinoma.
- Clinical observation and documentation of dermatologic toxicity, including HFS and its rare genital manifestation.
Main Results:
- The patient developed grade 2 HFS, characterized by typical palmar-plantar symptoms.
- Uncommon involvement of the genital area was observed alongside the standard HFS symptoms.
Conclusions:
- Atypical genital involvement can occur in capecitabine-induced HFS.
- Prompt recognition of HFS, including its rare presentations, is crucial for effective patient management and treatment adherence.
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