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Updated: Aug 5, 2026
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Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications
Published on: February 7, 2021
Multifunctional Injectable Hydrogel as a Biomimic Lens: Optical-Mechanical Restoration and Dynamic Postoperative
Renjie Zhang1, Yuemei Han1, Huiying Huang1
1National Engineering Research Center of Ophthalmology and Optometry, School of Biomedical Engineering, School of Ophthalmology and Optometry, Eye Hospital, Wenzhou Medical University, Wenzhou, China.
Advanced Materials (Deerfield Beach, Fla.)
|August 1, 2026
Summary
This study introduces an injectable hydrogel lens that restores natural vision after cataract surgery. The advanced biomimic lens offers continuous focus and actively heals the eye, reducing complications.
Area of Science:
- Biomaterials Science
- Ophthalmology
- Regenerative Medicine
Background:
- Current intraocular lenses (IOLs) for cataract treatment have limitations.
- Conventional IOLs lack biological adaptability and continuous accommodation.
- They can cause visual disturbances and postoperative complications.
Purpose of the Study:
- To develop an injectable, multifunctional hydrogel biomimic lens.
- To reconstruct optical-mechanical properties and modulate the ocular microenvironment.
- To overcome limitations of conventional intraocular lenses.
Main Methods:
- Injectable hydrogel formation via multilayered dynamic crosslinking.
- Micro-capsulorhexis-assisted in situ gelation within the capsular bag.
- Incorporation of drug-eluting and photocatalytic elements for therapeutic effects.
Main Results:
- The hydrogel formed a biomimic lens with continuous refractive properties.
- Postoperative functions included antibacterial, anti-inflammatory, and antifibrotic effects.
- Photocatalytic elements facilitated clearance of residual cells, restoring homeostasis.
- Rabbit models showed effective refractive reconstruction and suppressed complications.
Conclusions:
- The developed hydrogel lens offers a promising next-generation solution for cataract treatment.
- It effectively restores optical and mechanical functions while managing the ocular microenvironment.
- This approach holds potential for improved patient outcomes and reduced long-term complications.