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Gamma Knife Radiosurgery for Brain Metastasis from Primary Thyroid Cancer
Mehmet Ali Tepebasili1, Dogu Cihan Yildirim2, Ali Haluk Duzkalir2
1Koc University School of Medicine, Department of Neurosurgery, Istanbul, Türkiye.
Turkish Neurosurgery
|August 1, 2026
Summary
Gamma Knife radiosurgery (GKRS) shows promise for treating thyroid cancer brain metastases (TCBM), offering good local control with minimal side effects. Despite the aggressive nature of TCBM and short follow-up, GKRS appears effective.
Area of Science:
- Neurosurgery
- Oncology
- Radiotherapy
Background:
- Thyroid cancer brain metastases (TCBM) are rare but aggressive.
- Effective management strategies for TCBM are limited.
Purpose of the Study:
- To evaluate the efficacy and safety of Gamma Knife radiosurgery (GKRS) for TCBM.
- To assess local tumor control and adverse events following GKRS in TCBM patients.
Main Methods:
- Retrospective analysis of 10 patients with 40 TCBM treated with GKRS.
- Data collected on clinical outcomes, radiological results, and follow-up.
- Median GKRS dose of 23 Gy administered.
Main Results:
- Favorable local control rate of 95% for treated metastases.
- Radiation-induced necrosis occurred in one case, with no clinical impact.
- Median follow-up was 8 months, with 80% mortality, reflecting aggressive disease.
Conclusions:
- GKRS demonstrates favorable local control for TCBM with a low rate of adverse effects.
- Despite limitations of small sample size and short follow-up, GKRS is a potentially effective treatment option for TCBM.
- The aggressive nature of TCBM necessitates further research with longer follow-up periods.
