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Updated: Aug 5, 2026
Sentinel Lymph Node Mapping and Biopsy for Endometrial Cancer at Early Stage with Laparoscopy
Published on: August 19, 2021
Integrated virtual MR elastography and IVIM-DWI for preoperative prediction of lymph-vascular space invasion in
1Department of Radiology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China; Department of Graduate, Bengbu Medical University, Bengbu, China.
Aim:
To evaluate the diagnostic performance of combined virtual magnetic resonance elastography (vMRE) and intravoxel incoherent motion diffusion-weighted imaging (IVIM-DWI) in preoperative prediction of lymph-vascular space invasion (LVSI) in endometrial cancer (EC).
Materials And Methods:
This retrospective study included 80 EC patients confirmed by postoperative pathology (59 LVSI-negative and 21 LVSI-positive) who underwent preoperative vMRE and IVIM-DWI between June 2019 and April 2024. Quantitative parameters derived from vMRE (μdiff) and IVIM-DWI (standard ADC, D, D∗, f) were systematically compared between the two groups. Multivariable logistic regression and receiver operating characteristic (ROC) curve analyses were employed to evaluate the diagnostic performance of these parameters. Decision curve analysis was used to assess clinical usefulness.
Results:
The LVSI-positive group exhibited significantly higher μdiff values, lower D values, and larger maximal tumor diameters than the LVSI-negative group. Multivariable logistic regression identified μdiff, D value, and maximal tumor diameter as independent predictors of LVSI positivity (all P ≤ 0.05). The combined model achieved the highest diagnostic performance (AUC = 0.916, sensitivity = 86%, specificity = 80%). Decision curve analysis demonstrated superior clinical utility of the combined model compared with individual parameters.
Conclusion:
The integration of vMRE and IVIM-DWI enhances preoperative LVSI prediction in EC, providing a non-invasive tool for risk stratification and surgical planning.
