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Optimizing Weight Loss Maintenance: Can Continuous Glucose Monitoring Play a Role (OWL-CGM)? A Randomized Controlled
Nurul Zafirah Mohd Hatta1, Cindy M Gray2, Michelle Harvie3
1School of Cardiovascular and Metabolic Health, College of Medical Veterinary and Life Sciences, University of Glasgow, G12 8TA, United Kingdom.
Clinical Nutrition (Edinburgh, Scotland)
|August 1, 2026
Summary
Continuous glucose monitoring (CGM) aids weight loss maintenance. A personalized program with CGM led to greater weight loss and reduced calorie intake compared to a program without CGM over 24 weeks.
Area of Science:
- Metabolic Health
- Obesity Research
- Behavioral Medicine
Background:
- Weight loss maintenance presents a significant challenge for individuals aiming for long-term health improvements.
- Continuous glucose monitoring (CGM) offers potential biofeedback to support lifestyle modifications for weight management.
- Personalized weight loss maintenance programs (PWM) are being explored to enhance adherence and outcomes.
Purpose of the Study:
- To evaluate the feasibility of integrating CGM into a personalized, dietitian-led weight loss maintenance program (PWM).
- To determine if CGM use within a PWM enhances improvements in dietary intake, physical activity, body weight, body composition, and cardiometabolic risk biomarkers over 24 weeks.
- To assess the impact of CGM-assisted biofeedback on weight loss maintenance strategies.
Main Methods:
- A randomized controlled trial involving adults who had previously lost >5 kg.
- Participants were randomized to either a personalized weight loss maintenance program (PWM) or PWM combined with CGM (PWM/CGM).
- Both groups received dietitian consultations; the PWM/CGM group additionally used a CGM device for 24 weeks to guide behaviors.
Main Results:
- High adherence was observed, with 83.7% of randomized participants completing the study and high CGM wear time (92.6%) in the intervention group.
- The PWM/CGM group achieved significantly greater weight loss at 24 weeks compared to the PWM group (-2.7 kg vs +0.5 kg).
- Participants in the PWM/CGM group demonstrated a greater reduction in energy intake (-235 kcal/day) compared to the PWM group (+23 kcal/day).
Conclusions:
- Continuous glucose monitoring (CGM) is a feasible adjunct to intensive weight loss maintenance programs.
- The study supports the potential of CGM to enhance weight loss maintenance and dietary control.
- Findings warrant a fully-powered randomized controlled trial to confirm the long-term effectiveness of CGM in weight management.
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