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Cognitive reserve and functional outcome in euthymic Bipolar I Disorder
Shivanand Kattimani1, Jerry Abraham1
1Dept of Psychiatry, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Puducherry 605006, India.
Asian Journal of Psychiatry
|August 1, 2026
Summary
Cognitive reserve (CR) is linked to better daily functioning in people with bipolar disorder (BD-I), even when symptoms are managed. This suggests CR may be important for recovery and overall well-being in BD-I patients.
Area of Science:
- Neuroscience
- Psychiatry
- Psychology
Background:
- Functional impairment persists in bipolar disorder (BD) despite symptom remission.
- Cognitive reserve (CR) is hypothesized as a protective factor influencing recovery.
- Understanding factors affecting functional outcomes in BD is crucial for improving patient care.
Purpose of the Study:
- To investigate the association between cognitive reserve (CR) and functional outcomes in euthymic individuals with Bipolar I Disorder (BD-I).
Main Methods:
- A cross-sectional study involving 84 outpatients with DSM-5 BD-I.
- Assessment of CR using the Lifetime of Experiences Questionnaire (LEQ).
- Evaluation of functional outcome using the Functioning Assessment Short Test (FAST).
Main Results:
- Higher CR was significantly associated with better psychosocial functioning (rho = -0.27, p = 0.011).
- This association remained significant after controlling for demographic and illness-related variables (partial rho = -0.26, p = 0.022).
- Women and participants from middle socioeconomic groups exhibited higher CR scores.
Conclusions:
- Cognitive reserve plays a significant role in functional outcomes for individuals with Bipolar I Disorder.
- While CR is important, functional outcome is multifactorial, indicating the need for comprehensive treatment strategies.
- Findings support the potential of targeting CR to enhance functional recovery in BD-I.
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