Plasma IL-24 is associated with time to first fall in Parkinson's disease
Kazuhiro Iwaoka1, Keita Taguchi1, Sayuri Oikawa2
1Division of Neurology and Gerontology, Department of Internal Medicine, School of Medicine, Iwate Medical University, Yahaba, Iwate, Japan.
None:
Plasma inflammatory protein biomarkers associated with clinical milestone heterogeneity in Parkinson's disease (PD) remain undefined. We measured 92 inflammation-related plasma proteins in 82 PD patients using the Olink Proximity Extension Assay. No proteins differed significantly between fallers and non-fallers. However, among fallers, plasma interleukin-24 showed the strongest correlation with observed time to first fall (unadjusted r = 0.752, q = 0.071), and this signal was also observed in an exploratory covariate-adjusted model (q = 0.030). Colony-stimulating factor 1 showed a comparable but non-significant correlation. In group comparisons for symptomatic orthostatic hypotension, CCL11 differed significantly between patients with and without symptomatic orthostatic hypotension (q = 0.0004). These exploratory findings highlight candidate inflammatory protein profiles related to milestone heterogeneity in PD, warranting validation in longitudinal cohorts.
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