Related Experiment Video
Updated: Aug 5, 2026
07:17
Studying Orthodontic Tooth Movement in Mice
Published on: August 2, 2024
Targeting the immune-metabolic axis reverses orthodontics-induced systemic pathology
Yuning Zhang1,2, Shengjie Jiang2,3, Huimin Zheng2,3
1Department of Orthodontics, Peking University School and Hospital of Stomatology, Beijing, PR China.
Signal Transduction and Targeted Therapy
|August 2, 2026
Summary
Orthodontic treatment can cause systemic inflammation and liver issues by activating B cells and releasing IgM. Supplementing lysine and alanine may mitigate these side effects.
Area of Science:
- Immunology
- Orthodontics
- Metabolomics
Background:
- Orthodontic treatment induces alveolar bone remodeling.
- Systemic immune effects of orthodontic treatment are understudied.
Purpose of the Study:
- Investigate orthodontic treatment's impact on systemic immunity.
- Identify mechanisms and potential therapeutic targets.
Main Methods:
- Mechanical force application in orthodontic models.
- Immune cell profiling (CD69+ B cells).
- Mechanosensor identification (Piezo1+ macrophages).
- Multi-organ metabolomic analysis.
- Amino acid supplementation (lysine, alanine).
Main Results:
- Mechanical force triggers adaptive immune responses and systemic inflammation.
- Expansion of CD69+ B cells leads to IgM-driven liver dysfunction and impaired bone repair.
- Piezo1+ macrophages link mechanical force to B cell activation.
- Amino acid dysregulation exacerbates inflammation.
- Lysine and alanine supplementation reduced inflammation and improved outcomes.
Conclusions:
- Orthodontic therapy activates a systemic immune-metabolic axis.
- Targeting B cell-IgM pathways or metabolic dysregulation offers therapeutic potential.
- Amino acid supplementation may improve orthodontic treatment safety and efficacy.
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