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Spatiotemporal Sonodynamic-Nanozymic Therapy for Infected Jawbone Defects
Xin Liu1, Zifan Zhao1, Liujixiang Wang1
1State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine Ministry of Education, Hubei Key Laboratory of Stomatology, School & Hospital of Stomatology, Wuhan University, Wuhan, P.R. China.
This study introduces a novel hydrogel platform (CuZn-MON@gel) for treating infectious jawbone defects. It effectively kills bacteria, reduces inflammation, and promotes bone regeneration, offering a promising therapeutic strategy.
Area of Science:
- Biomaterials Science
- Orthopedic Surgery
- Nanotechnology
Background:
- Infectious jawbone defects involve bone loss and chronic infection, posing significant clinical challenges.
- Current treatments struggle with pathogen control, immune modulation, and osteogenesis activation.
Purpose of the Study:
- To develop a multifunctional platform for spatiotemporal treatment of infectious bone defects.
- To evaluate the antibacterial, anti-inflammatory, and osteogenic capabilities of the platform.
Main Methods:
- Constructed a hydrogel encapsulating copper-zinc bimetallic metal-organic nanosheets (CuZn-MON@gel).
- Utilized ultrasound to activate CuZn-MON for singlet oxygen generation and antibacterial effects.
- Assessed nanozyme activity for reactive oxygen species scavenging and anti-inflammatory effects.
- Investigated the release of Cu2+ and Zn2+ ions to promote osteogenesis.
Main Results:
- Achieved high antibacterial efficiencies against Staphylococcus aureus (99.93%) and Porphyromonas gingivalis (99.78%) upon ultrasound irradiation.
- Demonstrated SOD- and CAT-like activities to scavenge reactive oxygen species and downregulate inflammatory pathways.
- Showcased enhanced osteogenic marker expression (Runx2, ALP, OCN, OPN) via AMPK and PI3K/Akt pathways.
- Accelerated bone regeneration and repaired jawbone defects in an infected rat model.
Conclusions:
- CuZn-MON@gel provides a dynamic, spatiotemporal therapeutic strategy for infectious bone defects.
- The platform balances bactericidal ROS generation with antioxidant protection for effective bone repair.
- This approach shows significant potential for reconstructing infectious bone defects and promoting jawbone regeneration.
