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Spatiotemporal Sonodynamic-Nanozymic Therapy for Infected Jawbone Defects
Xin Liu1, Zifan Zhao1, Liujixiang Wang1
1State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine Ministry of Education, Hubei Key Laboratory of Stomatology, School & Hospital of Stomatology, Wuhan University, Wuhan, P.R. China.
This study presents a novel hydrogel platform (CuZn-MON@gel) for treating infectious jawbone defects. It effectively kills bacteria, reduces inflammation, and promotes bone regeneration, offering a new therapeutic strategy.
Area of Science:
- Biomaterials Science
- Orthopedic Surgery
- Infectious Diseases
Background:
- Infectious jawbone defects involve bone loss and chronic infection, posing significant clinical challenges.
- Current treatments struggle with pathogen control, immune modulation, and osteogenesis activation.
Purpose of the Study:
- To develop a multifunctional platform for spatiotemporal treatment of infectious bone defects.
- To evaluate the antibacterial, anti-inflammatory, and osteogenic potential of the platform.
Main Methods:
- Construction of copper-zinc bimetallic metal-organic nanosheets in a hydrogel (CuZn-MON@gel).
- Ultrasound-triggered singlet oxygen generation for antibacterial effects.
- Nanozyme activity for reactive oxygen species scavenging and anti-inflammatory effects.
- Controlled release of ions to activate osteogenic pathways.
Main Results:
- Achieved >99.9% bacterial reduction against Staphylococcus aureus and Porphyromonas gingivalis.
- Demonstrated antioxidant and anti-inflammatory properties by modulating signaling pathways.
- Promoted osteogenic differentiation and accelerated bone regeneration in a rat model.
Conclusions:
- CuZn-MON@gel provides a dynamic therapeutic strategy for infectious bone defects.
- The platform effectively balances bactericidal action with bone repair.
- This approach shows promise for reconstructing infected jawbone defects.
