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Glioblastoma in a Patient With MELAS Syndrome: A Case Report
Seung Min Chang1, Hun Ho Park1, Ji Hyun Park2
1Department of Neurosurgery, Brain Tumor Center, Gangnam Severance Hospital, Seoul, Korea.
Brain Tumor Research and Treatment
|August 3, 2026
Summary
This case highlights a rare glioblastoma in a patient with Mitochondrial Encephalomyopathy, Lactic Acidosis, and Stroke-like episodes (MELAS) syndrome. The aggressive tumor recurred rapidly, suggesting mitochondrial dysfunction may impact brain cancer progression and treatment.
Area of Science:
- Neuro-oncology
- Mitochondrial Medicine
- Genetics
Background:
- Mitochondrial Encephalomyopathy, Lactic Acidosis, and Stroke-like episodes (MELAS) syndrome is a rare genetic disorder causing mitochondrial dysfunction.
- Clinical presentation of MELAS is diverse, often involving neurological and metabolic symptoms.
