Precision Endodontics-Advancing Towards Omics-Guided Personalisation: A Narrative Review

Area of Science:

• Biomedical Sciences
• Dental Sciences
• Precision Medicine

Background:

• Conventional endodontic treatments often follow a 'one-size-fits-all' approach.
• Emerging omics technologies offer potential for a more personalized approach to endodontics.

Purpose of the Study:

• To critically evaluate the contribution of genomics, transcriptomics, proteomics, metabolomics, and microbiomics to precision endodontics.
• To examine the opportunities and challenges of integrating omics technologies into clinical endodontic practice.

Main Methods:

• A narrative review of recent literature in biomedical and dental sciences.
• Synthesis of endodontic research and principles of translational precision medicine and dentistry.
• Assessment of potential applications of omics technologies in endodontics.

Main Results:

• Omics technologies enhance understanding of pulpal and periapical diseases, identifying biomarkers for diagnosis and prognosis.
• Genomic and transcriptomic studies reveal molecular signatures of host response and tissue repair.
• Proteomic, metabolomic, and microbiomic analyses offer insights into disease characterization, vitality, healing, and targeted disinfection.
• Integration of multi-omics data with AI can create predictive models for personalized care, but validation and standardization challenges remain.

Conclusions:

• Precision endodontics, guided by omics data, represents an evolution towards tailored interventions.
• Synergistic integration of omics and AI may pave the way for next-generation individualized endodontic therapies.
• Translating omics-driven approaches into clinical tools is in its early stages, requiring rigorous validation and practical frameworks.