Related Experiment Video
Updated: Aug 5, 2026
07:02
In Vivo Inhibition of MicroRNA to Decrease Tumor Growth in Mice
Published on: August 23, 2019
RETRACTION: MicroRNA-106b Regulates the Tumor Suppressor RUNX3 in Laryngeal Carcinoma Cells
FEBS Letters
|August 3, 2026
Summary
This study investigated microRNA-106b's role in laryngeal carcinoma, finding it regulates the tumor suppressor RUNX3. However, the article was retracted due to significant data duplication issues.
Area of Science:
- Oncology
- Molecular Biology
- Biochemistry
Background:
- Laryngeal carcinoma is a significant health concern.
- MicroRNAs (miRNAs) play crucial roles in cancer development.
- RUNX3 is a known tumor suppressor gene.
Purpose of the Study:
- To investigate the role of microRNA-106b (miR-106b) in laryngeal carcinoma.
- To determine if miR-106b regulates the tumor suppressor RUNX3 in laryngeal carcinoma cells.
Main Methods:
- The study involved cell culture experiments using laryngeal carcinoma cells.
- Techniques likely included miRNA expression analysis, gene silencing, and protein level detection.
- Quantitative real-time PCR was used to assess gene expression.
Main Results:
- The article reported that miR-106b regulates RUNX3 expression in laryngeal carcinoma cells.
- Specific figures indicated effects of miR-106b on RUNX3 levels.
Conclusions:
- The original study concluded that miR-106b acts as an oncogene by downregulating the tumor suppressor RUNX3.
- However, the article has been retracted due to data integrity concerns, compromising its findings.
Related Concept Videos
01:22MicroRNAs
MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA ends...
01:22MicroRNAs
MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
02:23Abnormal Proliferation
Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the daughter...
01:20The Retinoblastoma Gene
Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...
02:39lncRNA - Long Non-coding RNAs
In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA (lncRNA)...
03:17Inheritance of Chromatin Structures
Epigenetics is the study of inherited changes in a cell's phenotype without changing the DNA sequences. It provides a form of memory for the differential gene expression pattern to maintain cell lineage, position-effect variegation, dosage compensation, and maintenance of chromatin structures such as telomeres and centromeres. For example, the structure and location of the centromere on chromosomes are epigenetically inherited. Its functionality is not dictated or ensured by the underlying DNA...