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Treatment of Tuberculosis in Renal Insufficiency
Nikhil Gupta1, Harshita Rani2, Rishabh Kacker2
1Professor, Department of General Medicine, Dr. Ram Manohar Lohia Institute of Medical Sciences, Lucknow, Uttar Pradesh, India, Corresponding Author.
Abstract:
Tuberculosis (TB) is a significant global health challenge, particularly in patients with renal insufficiency, where both the disease and its treatment are complicated by altered pharmacokinetics, immunosuppression, and increased risk of drug toxicity. Management of TB in patients with renal insufficiency is complex and necessitates an individualized, multidisciplinary approach. Careful dose adjustments, regimen selection, management of comorbid conditions, regular monitoring, and adherence to current guidelines can optimize outcomes while minimizing adverse effects. This article reviews current strategies and evidence-based approaches for the treatment of TB in patients with renal insufficiency, with a focus on drug selection, dose adjustment, and monitoring for toxicity and efficacy.
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