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Published on: April 6, 2012
Galectin-3 Negatively Regulates miR-31 Processing in Breast Cancer Cells
Gi Soo Youn, Woo Young Lim, Yubin Kim
1Department of Biomedical Science, Hallym University, Chuncheon, Gangwon State 24252, Republic of Korea; Multidisciplinary Genome Institute, Hallym University, Chuncheon, Republic of Korea.
BMB Reports
|August 3, 2026
Summary
Galectin-3 negatively regulates microRNA-31 (miR-31) maturation in breast cancer. This study reveals Galectin-3 binds pre-miR-31, inhibiting its processing and leading to reduced tumor suppressor miR-31 levels in cancer cells.
Area of Science:
- Molecular Biology
- Cancer Research
- Biochemistry
Background:
- MicroRNA-31 (miR-31) functions as a tumor suppressor but is downregulated in breast cancer.
- The mechanism behind reduced miR-31 maturation in breast cancer remains largely unknown.
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