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Inflammatory and Oxidative Biomarkers in Ischemic Stroke
Trisha C1, Naveen Ch2, Prabhat Kumar N3
1Internal Medicine, Chalmeda AnandRao Institute of Medical Sciences, Karimnagar, IND.
Cureus
|August 3, 2026
Summary
Acute ischemic stroke patients exhibit elevated inflammatory markers and oxidative stress, with reduced antioxidant levels. These biomarkers correlate with stroke severity and may aid in assessing vascular injury.
Area of Science:
- Neurology
- Biochemistry
- Pathophysiology
Background:
- Ischemic stroke involves inflammation, endothelial dysfunction, and oxidative stress.
- Biochemical changes impact neuronal damage and clinical severity.
- Biomarkers are crucial for understanding stroke progression.
Purpose of the Study:
- Evaluate inflammatory and oxidative stress biomarkers in acute ischemic stroke.
- Compare biomarker levels between stroke patients and healthy controls.
- Assess the correlation between biomarkers and stroke severity.
Main Methods:
- A case-control study included 50 ischemic stroke patients and 50 healthy controls.
- Serum levels of C-reactive protein (CRP), interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-α), malondialdehyde (MDA), nitric oxide (NO), superoxide dismutase (SOD), catalase, and reduced glutathione (GSH) were analyzed.
- Stroke severity was assessed using the National Institutes of Health Stroke Scale (NIHSS).
Main Results:
- Stroke patients showed significantly higher levels of CRP, IL-6, TNF-α, MDA, and NO compared to controls.
- Antioxidant markers (SOD, catalase, GSH) were significantly lower in stroke patients.
- CRP, IL-6, and MDA levels positively correlated with NIHSS scores, indicating a link to stroke severity.
Conclusions:
- Ischemic stroke is characterized by significant inflammation and oxidative imbalance.
- Elevated inflammatory markers and oxidative stress, coupled with reduced antioxidant capacity, are key features.
- These biomarkers may be valuable for assessing stroke severity and vascular injury.
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