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Updated: Aug 5, 2026
09:42
Murine Endoscopy for In Vivo Multimodal Imaging of Carcinogenesis and Assessment of Intestinal Wound Healing and Inflammation
Published on: August 26, 2014
Role of functional endoscopy
Ippei Tanaka1,2, Haruhiro Inoue1
1Digestive Disease Center, Showa Medical University Koto Toyosu Hospital, Tokyo, Japan.
Clinical Endoscopy
|August 3, 2026
Summary
Functional endoscopy using the endoscopic pressure-integrated system (EPSIS) shows promise for diagnosing gastrointestinal disorders like acid reflux and achalasia. Further multicenter studies are needed to confirm its clinical utility.
Area of Science:
- Gastroenterology
- Endoscopic technology
- Functional diagnostics
Background:
- Endoscopy is advancing to assess gastrointestinal function, termed functional endoscopy.
- The endoscopic pressure-integrated system (EPSIS) is a key technology in this evolving field.
Purpose of the Study:
- To review current evidence on the diagnostic and therapeutic evaluation capabilities of the endoscopic pressure-integrated system (EPSIS).
- To explore the potential of EPSIS in assessing gastroesophageal reflux disease (GERD), achalasia, and treatment outcomes.
Main Methods:
- Review of existing studies on the endoscopic pressure-integrated system (EPSIS).
- Analysis of associations between EPSIS parameters and traditional diagnostic methods (e.g., 24-hour pH monitoring).
- Evaluation of EPSIS in diagnosing conditions and assessing treatment efficacy.
Main Results:
- EPSIS demonstrated diagnostic utility for GERD, correlating with pH monitoring and endoscopic findings like erosive esophagitis and Barrett's esophagus.
- EPSIS proved useful in diagnosing achalasia and evaluating treatment effectiveness after antireflux procedures.
- Dynamic changes in gastric cardia pressure during EPSIS were described by the 'phase concept,' showing dysfunction in acid reflux patients.
Conclusions:
- The endoscopic pressure-integrated system (EPSIS) shows significant potential in functional gastrointestinal diagnostics.
- Further multicenter prospective studies are essential to validate findings and establish widespread clinical application of EPSIS.
- Clarification of remaining aspects of EPSIS technology is needed for broader adoption.
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