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Split Hybridization Probe Utilizing a DNA Fluorescent Light-up Aptamer as a Signal Reporter for Sequence-Specific Nucleic Acid Analysis
Published on: July 8, 2025
Target triggered catalytic hairpin assembly lights up darkish DNA-silver nanoclusters for amplified fluorescence
Li Sun1, Yue Liu2, Chengquan Wang1
1School of Food Science and Engineering, Jiangsu University, Zhenjiang 212013, P. R. China.
Chemical Communications (Cambridge, England)
|August 3, 2026
Abstract:
Target-triggered catalytic hairpin assembly lights up darkish DNA-templated silver nanoclusters through proximity-induced activation by a G-rich fluorescence enhancer. Beyond being label-free, this lighting-up fluorescence biosensor requires neither quenchers nor separation steps, greatly simplifying the operation.
