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Published on: June 14, 2019
Coreactant-specific electrochemiluminescence of an anthracene-based zinc framework for detection of HPV-16 DNA
Zheng Tao1, Yufei Wang1, Xueyi Zheng1
1State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, 210023, China. jpl@nju.edu.cn.
Abstract:
The efficient activation of a coreactant is challenging in electrochemiluminescence (ECL) enhancement. Herein, a metal-organic framework nanoemitter was designed with an anthracene derivative as a luminophore ligand and a Zn2+ node. It demonstrated a 1,4-diazabicyclo[2.2.2]octane (DABCO)-specific ECL pathway via coordination interaction between the coreactant and the Zn2+ node, which significantly enhanced emission over conventional coreactants, establishing a sensitive strategy for DNA detection.
