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A Nonviral Approach to Generate Transient Chimeric Antigen Receptor T Cells Using mRNA for Cancer Immunotherapy
Published on: February 21, 2025
[Advances in the Study of Factors Influencing the Efficacy of CAR-T Cell Therapy in Hematologic Oncology
Li-Mei Li1, Xun Lai1, Hong-Jing Yin2
1Department of Haematology, The Third Affiliated Hospital of Kunming Medical University,Kunming 650101, Yunnan Province, China.
Abstract:
Chimeric antigen receptor T cell (CAR-T) therapy is a revolutionary progress in the current field of tumor treatment, especially showing remarkable potential in relapsed/refractory hematological malignancies. However, there are significant differences in efficacy among different patients, and such differences are affected by multiple clinical and biomedical factors. This review will discuss the current application status of CAR-T therapy in hematological malignancies, analyze the key factors influencing the efficacy, and summarize the latest research trends and development directions in this field, so as to provide references for clinical decision - making and scientific research innovation.
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