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Targeting Neuronal Fiber Tracts for Deep Brain Stimulation Therapy Using Interactive, Patient-Specific Models
Published on: August 12, 2018
A Gap Analysis of Deep Brain Stimulation for Childhood-Onset Movement Disorders
Daniela Munoz-Chesta1,2,3, Carolina Gorodetsky4, Todd M Herrington5
1Department of Pediatric Neurology and Psychiatry, San Borja Arriaran Hospital, University of Chile, Santiago, Chile.
Summary
Deep brain stimulation (DBS) for pediatric movement disorders faces challenges. Emerging strategies and international collaboration are key to improving care and access for children requiring this advanced neuromodulation therapy.
Area of Science:
- Neurology
- Neurosurgery
- Pediatric Movement Disorders
Background:
- Deep brain stimulation (DBS) is a recognized therapy for childhood-onset movement disorders.
- Current adult-derived DBS protocols present significant challenges for pediatric applications.
Purpose of the Study:
- Identify critical gaps in pediatric DBS.
- Highlight emerging strategies tailored for children across the care pathway.
Main Methods:
- Expert opinion from seven experienced pediatric DBS clinicians and researchers.
- Focused literature review on current gaps in pediatric DBS.
Main Results:
- Gaps persist in standardized pediatric selection, biomarkers, outcome definition, and global access.
- Emerging strategies include individualized, genotype-informed approaches, and technological advancements.
Conclusions:
- Pediatric DBS requires specialized frameworks and approaches.
- Individualized strategies, technological innovation, and global collaboration are crucial for advancing pediatric DBS.
