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A Microwave-Assisted Direct Heteroarylation of Ketones Using Transition Metal Catalysis
Published on: February 16, 2020
Weakly coordinating ketone-directed ortho-C-H olefination of biaryl ketones under microwave-assisted palladium
Kurella Mounika1, Gedu Satyanarayana1
1Indian Institute of Technology Hyderabad, Kandi, Sangareddy, Telangana 502285, India. gvsatya@chy.iith.ac.in.
Abstract:
Selective C-H functionalization directed by weakly coordinating groups remains a challenging yet valuable strategy in organic synthesis. In this study, biaryl ketones underwent microwave-assisted palladium-catalyzed ortho-C-H olefination, with the ketone group serving as the directing group. The transformation proceeded across a range of substrates and olefin partners, delivering the coupled products in moderate to good yields with high regioselectivity and broad functional-group tolerance. Notably, the strategy is amenable to generating drug-derived molecules, and post-synthetic transformations were also explored.
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