Related Experiment Videos

Impact of Severe Postoperative Multi-Organ Dysfunction on Long-Term Outcomes After Modified Morrow Surgery

Tong Wang1, La Ta1, Kui Zhang1

  • 1Institute of Cardiac Surgery, Beijing An Zhen Hospital Capital Medical University, Beijing, China.

Clinical Cardiology
|August 3, 2026
PubMed

Insights

Severe multi-organ dysfunction after hypertrophic obstructive cardiomyopathy surgery increases long-term risks. The Sequential Organ Failure Assessment (SOFA) score can identify patients needing closer monitoring post-surgery.

Area of Science:

  • Cardiology
  • Surgical Outcomes
  • Critical Care Medicine

Background:

  • Modified Morrow surgery is standard for hypertrophic obstructive cardiomyopathy (HOCM).
  • Postoperative severe multi-organ dysfunction is a known risk.
  • Long-term cardiovascular outcomes post-surgery require further investigation.

Purpose of the Study:

  • To evaluate the association between severe multi-organ dysfunction and long-term cardiovascular outcomes in HOCM patients.
  • To identify predictors of adverse events after modified Morrow surgery.

Main Methods:

  • Observational cohort study of 380 HOCM patients undergoing modified Morrow surgery.
  • Severe multi-organ dysfunction defined by maximum Sequential Organ Failure Assessment (SOFA) score ≥ 11.
  • Primary endpoint: major adverse cardiac and cerebrovascular events (MACCEs); secondary endpoints: heart failure hospitalization, atrial fibrillation ablation, cardiovascular mortality.

Main Results:

  • Patients with severe multi-organ dysfunction (SOFA ≥ 11) had significantly higher MACCEs (53.4% vs. 17.5%), cardiovascular mortality (11.6% vs. 0.9%), heart failure hospitalization (21.9% vs. 8.5%), and atrial fibrillation ablation (17.8% vs. 3.8%).
  • Severe multi-organ dysfunction independently predicted cardiovascular mortality (HR=4.157), MACCEs (HR=2.296), heart failure hospitalization (HR=1.834), and atrial fibrillation ablation (HR=3.987).
  • Other predictors included family history of HOCM, left ventricular dimensions, and postoperative ventilation time.

Conclusions:

  • Postoperative severe multi-organ dysfunction is a significant independent predictor of adverse long-term outcomes after modified Morrow surgery.
  • Utilizing the SOFA score for postoperative risk stratification can aid in identifying high-risk HOCM patients.
  • Intensified long-term management strategies may be warranted for patients identified with severe multi-organ dysfunction.
Abstract

Keywords:
SOFA scorehypertrophic obstructive cardiomyopathylong‐term outcomesmajor adverse cardiac and cerebrovascular eventsmodified morrow surgerymulti‐organ dysfunction

Related Concept Videos

Cardiomyopathy VII: Pre and Post Operative Nursing Management01:28

Cardiomyopathy VII: Pre and Post Operative Nursing Management

Patients with hypertrophic cardiomyopathy (HCM) and left ventricular outflow tract (LVOT) obstruction who remain symptomatic despite optimal medical therapy may undergo a septal myectomy (Morrow procedure). This procedure involves excising a portion of the hypertrophied septum below the aortic valve using a heart-lung machine to improve blood flow through the LVOT. Effective preoperative and postoperative nursing management ensures successful patient outcomes, minimizes complications, and...
Peripheral Artery Disease V: Postoperative Nursing Management01:23

Peripheral Artery Disease V: Postoperative Nursing Management

During the postoperative period, it is crucial to focus on maintaining circulation, identifying and managing potential complications, and planning for discharge.Nursing AssessmentVital signs monitoring: Regularly monitor vital signs, including blood pressure, heart rate, respiratory rate, and temperature, to detect early signs of complications such as bleeding and infection.Circulation assessment: Monitor pulses, perform Doppler assessments, and check capillary refill, color, temperature, and...
Tissue Transplantation01:24

Tissue Transplantation

Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...